Parsing consumption preferences of music streaming audiences

As demands for insights on music streaming listeners continue to grow, scientists and industry analysts face the challenge to comprehend a mutated consumption behavior, which demands a renewed approach to listener typologies. This study aims to determine how audience segmentation can be performed in a time-relevant and replicable manner. Thus, it interrogates which parameters best serve as indicators of preferences to ultimately assist in delimiting listener segments. Accordingly, the primary objective of this research is to develop a revised typology that classifies music streaming listeners in the light of the progressive phenomenology of music listening. The hypothesis assumes that this could be solved by positioning listeners – rather than products – at the center of streaming analysis and supplementing sales- with user-centered metrics. The empirical research of this paper was based on grounded theories, enriched by analytical case studies. For this purpose, behavioral and psychological research results were interconnected with market analysis and streaming platform usage data. Analysis of the results demonstrates that a concatenation of multi-dimensional data streams facilitates the derivation of a typology that is applicable to varying audience pools. The findings indicate that for the delimitation of listener types, the motivation, and listening context are essential key constituents. Since these variables demand insights that reach beyond existing metrics, descriptive data points relating to the listening process are subjoined. Ultimately, parameter indexation results in listener profiles that offer novel access points for investigations, which make imperceptible, interdisciplinary correlations tangible. The framework of the typology can be consulted in analytical and creational processes. In this respect, the results of the derived analytical approach contribute to better determine and ultimately satisfy listener preferences.Während die Nachfrage nach Erkenntnissen über Musik-Streaming-Hörer kontinuierlich steigt, stehen Wissenschaftler sowie Industrieanalysten einem geänderten Konsumptions- verhalten gegenüber, das eine überarbeitete Hörertypologie fordert. Die vorliegende Studie erörtert, wie eine Hörersegmentierung auf zeitgemäße und replizierbare Weise umgesetzt werden kann. Demnach beschäftigt sie sich mit der Frage, welche Parameter am besten als Indikatoren für Hörerpräferenzen dienen und wie diese zur Abgrenzung der Publikumsseg- mente beitragen können. Dementsprechend ist es das primäre Ziel dieser Forschung, eine überarbeitete Typologie aufzustellen, die Musik-Streaming-Hörer in Anbetracht der progressiven Erscheinungsform des Musikhörens klassifiziert. Die Hypothese nimmt an, dass dies realisierbar ist, wenn der Hörer – anstelle von Produkten – im Zentrum der Streaming-Analyse steht und absatzzen- trierte durch hörerzentrierte Messungen ergänzt werden. Die empirische Forschung basiert auf systematischen Theorien, untermauert durch analytische Fallbeispiele. Hierfür werden psychologische und verhaltenswissenschaftliche Forschungserkenntnisse mit Marktanalysen und Nutzerdaten von Musikstreaming-Portalen fusioniert. Die Analyse der Ergebnisse verdeutlicht, dass eine Verkettung von multidimensionalen Rohdaten die Erhebung einer Typologie ermöglicht, die auf mehrere Hörergruppen anwend- bar ist. Die Befunde signalisieren, dass die Hörmotivation und der Hörkontext bei der Abgrenzung der Publikumstypen Schlüsselelemente darstellen. Da diese Variablen spezifis- che Kenntnisse fordern, die über vorliegende Kennzahlen hinausgehen, werden deskriptive Datenpunkte über den Hörvorgang ergänzt. Letztlich, resultiert die Indexierung der Pa- rameter in Hörerprofilen, die neue Zugangspunkte für Untersuchungen bieten, die nicht ersichtliche, interdisziplinäre Korrelationen greifbar machen. Das Gerüst der Hörertypologie kann sowohl in Erstellungs- als auch in Analyseprozessen herangezogen werden. Somit tragen die Ergebnisse der entwickelten Analysemethode zum Verständnis und letztlich zur Erfüllung von Hörerpräferenzen bei

Parsing consumption preferences of music streaming audiences

As demands for insights on music streaming listeners continue to grow, scientists and industry analysts face the challenge to comprehend a mutated consumption behavior, which demands a renewed approach to listener typologies. This study aims to determine how audience segmentation can be performed in a time-relevant and replicable manner. Thus, it interrogates which parameters best serve as indicators of preferences to ultimately assist in delimiting listener segments. Accordingly, the primary objective of this research is to develop a revised typology that classifies music streaming listeners in the light of the progressive phenomenology of music listening. The hypothesis assumes that this could be solved by positioning listeners – rather than products – at the center of streaming analysis and supplementing sales- with user-centered metrics. The empirical research of this paper was based on grounded theories, enriched by analytical case studies. For this purpose, behavioral and psychological research results were interconnected with market analysis and streaming platform usage data. Analysis of the results demonstrates that a concatenation of multi-dimensional data streams facilitates the derivation of a typology that is applicable to varying audience pools. The findings indicate that for the delimitation of listener types, the motivation, and listening context are essential key constituents. Since these variables demand insights that reach beyond existing metrics, descriptive data points relating to the listening process are subjoined. Ultimately, parameter indexation results in listener profiles that offer novel access points for investigations, which make imperceptible, interdisciplinary correlations tangible. The framework of the typology can be consulted in analytical and creational processes. In this respect, the results of the derived analytical approach contribute to better determine and ultimately satisfy listener preferences.Während die Nachfrage nach Erkenntnissen über Musik-Streaming-Hörer kontinuierlich steigt, stehen Wissenschaftler sowie Industrieanalysten einem geänderten Konsumptions- verhalten gegenüber, das eine überarbeitete Hörertypologie fordert. Die vorliegende Studie erörtert, wie eine Hörersegmentierung auf zeitgemäße und replizierbare Weise umgesetzt werden kann. Demnach beschäftigt sie sich mit der Frage, welche Parameter am besten als Indikatoren für Hörerpräferenzen dienen und wie diese zur Abgrenzung der Publikumsseg- mente beitragen können. Dementsprechend ist es das primäre Ziel dieser Forschung, eine überarbeitete Typologie aufzustellen, die Musik-Streaming-Hörer in Anbetracht der progressiven Erscheinungsform des Musikhörens klassifiziert. Die Hypothese nimmt an, dass dies realisierbar ist, wenn der Hörer – anstelle von Produkten – im Zentrum der Streaming-Analyse steht und absatzzen- trierte durch hörerzentrierte Messungen ergänzt werden. Die empirische Forschung basiert auf systematischen Theorien, untermauert durch analytische Fallbeispiele. Hierfür werden psychologische und verhaltenswissenschaftliche Forschungserkenntnisse mit Marktanalysen und Nutzerdaten von Musikstreaming-Portalen fusioniert. Die Analyse der Ergebnisse verdeutlicht, dass eine Verkettung von multidimensionalen Rohdaten die Erhebung einer Typologie ermöglicht, die auf mehrere Hörergruppen anwend- bar ist. Die Befunde signalisieren, dass die Hörmotivation und der Hörkontext bei der Abgrenzung der Publikumstypen Schlüsselelemente darstellen. Da diese Variablen spezifis- che Kenntnisse fordern, die über vorliegende Kennzahlen hinausgehen, werden deskriptive Datenpunkte über den Hörvorgang ergänzt. Letztlich, resultiert die Indexierung der Pa- rameter in Hörerprofilen, die neue Zugangspunkte für Untersuchungen bieten, die nicht ersichtliche, interdisziplinäre Korrelationen greifbar machen. Das Gerüst der Hörertypologie kann sowohl in Erstellungs- als auch in Analyseprozessen herangezogen werden. Somit tragen die Ergebnisse der entwickelten Analysemethode zum Verständnis und letztlich zur Erfüllung von Hörerpräferenzen bei

Effectiveness and safety of opicapone in Parkinson’s disease patients with motor fluctuations: the OPTIPARK open-label study

Background The efficacy and safety of opicapone, a once-daily catechol-O-methyltransferase inhibitor, have been established in two large randomized, placebo-controlled, multinational pivotal trials. Still, clinical evidence from routine practice is needed to complement the data from the pivotal trials. Methods OPTIPARK (NCT02847442) was a prospective, open-label, single-arm trial conducted in Germany and the UK under clinical practice conditions. Patients with Parkinson’s disease and motor fluctuations were treated with opicapone 50 mg for 3 (Germany) or 6 (UK) months in addition to their current levodopa and other antiparkinsonian treatments. The primary endpoint was the Clinician’s Global Impression of Change (CGI-C) after 3 months. Secondary assessments included Patient Global Impressions of Change (PGI-C), the Unified Parkinson’s Disease Rating Scale (UPDRS), Parkinson’s Disease Questionnaire (PDQ-8), and the Non-Motor Symptoms Scale (NMSS). Safety assessments included evaluation of treatment-emergent adverse events (TEAEs) and serious adverse events (SAEs). Results Of the 506 patients enrolled, 495 (97.8%) took at least one dose of opicapone. Of these, 393 (79.4%) patients completed 3 months of treatment. Overall, 71.3 and 76.9% of patients experienced any improvement on CGI-C and PGI-C after 3 months, respectively (full analysis set). At 6 months, for UK subgroup only (n = 95), 85.3% of patients were judged by investigators as improved since commencing treatment. UPDRS scores at 3 months showed statistically significant improvements in activities of daily living during OFF (mean ± SD change from baseline: − 3.0 ± 4.6, p < 0.0001) and motor scores during ON (− 4.6 ± 8.1, p < 0.0001). The mean ± SD improvements of − 3.4 ± 12.8 points for PDQ-8 and -6.8 ± 19.7 points for NMSS were statistically significant versus baseline (both p < 0.0001). Most of TEAEs (94.8% of events) were of mild or moderate intensity. TEAEs considered to be at least possibly related to opicapone were reported for 45.1% of patients, with dyskinesia (11.5%) and dry mouth (6.5%) being the most frequently reported. Serious TEAEs considered at least possibly related to opicapone were reported for 1.4% of patients. Conclusions Opicapone 50 mg was effective and generally well-tolerated in PD patients with motor fluctuations treated in clinical practice. Trial registration Registered in July 2016 at clinicaltrials.gov (NCT02847442)

Protic thiocyanate ionic liquids as fuels for hypergolic bipropellants with hydrogen peroxide

The combination of ionic liquids (ILs) and hydrogen peroxide is one of the most promising approaches for the substitution of conventionally used hypergolic bipropellants consisting of nitrogen tetroxide and hydrazines. In this work, protic ionic liquids with imidazolium-based cationic structures and thiocyanate anions are presented as new fuels for green hypergolic bipropellants for the first time. All seven presented substances are hypergolic with hydrogen peroxide and surpass the density specific impulse of the previously mentioned conventional bipropellant. One of them stands out in particular, as no other transition metal-, hydride- and boron-free ionic liquid with an ignition delay time as short as 7.3 ms was found with hydrogen peroxide so far. This extremely good ignition behavior of the, at room temperature solid, IL offers great potential not only for hybrid propellants, but also for liquid hypergolic bipropellant combinations: out of a mixture of 35 wt% [Him][SCN] and 65 wt% [Emim][SCN], a remarkable new liquid bipropellant combination (named HIM_35) is formed with a very low ignition delay time of 16.7 ms and a particularly high maximum density specific impulse ρ Isp of 429 s⋅g⋅cm- 3

Caution encouraged in next-generation sequencing immunogenetic analyses in acute lymphoblastic leukemia

International audienc

Variation in vancomycin dosing and therapeutic drug monitoring practices in neonatal intensive care units

Background Vancomycin is a frequently used antibiotic in neonates. However, there is no consensus guideline on the optimal dosing regimen and therapeutic drug monitoring (TDM) practices in this patient population. Objective To document the variability in the current dosing and TDM practices in neonatal intensive care units (NICU). Setting Belgian and Dutch NICUs. Method An online questionnaire was disseminated by e-mail to potential respondents. Main outcome measure Differences in vancomycin dosing and TDM practices in comparison with a reference source, the Dutch Paediatric Formulary. Results Eighteen NICUs (response rate 62%) participated. Eleven different dosing regimens are applied, with 83% using intermittent dosing regimens. Stratifying covariates used to determine the (initial) dosage include gestational age, postnatal age, serum creatinine, concurrent use of non-steroidal anti-inflammatory drugs, birth weight and current weight. Large variability is observed with regard to TDM practice as well, both for the concentration target range and the times of (re)sampling. Dosing calculators are more commonly used in the Netherlands than Belgium. Conclusion Significant inter-centre variability in dosing and TDM practices was found. The development of international consensus guidelines is required to optimize therapy. Dosing calculators to guide dosing are not yet considered as part of standard-of-care

Factors Controlling Regional Differences in Forest Soil Emission of Nitrogen Oxides (NO and N2O)

Soil emissions of NO and N2O were measured continuously at high frequency for more than one year at 15 European forest sites as part of the EU-funded project NOFRETETE. The locations represent different forest types (coniferous/deciduous) and different nitrogen loads. Geographically they range from Finland in the north to Italy in the south and from Hungary in the east to Scotland in the west.JRC.H.2-Climate chang